London's East End, 1957

In the Nightingale Hospital, Matron Helen finds herself playing surrogate mother to her newly discovered French niece Catrine, while having to keep their family relationship a secret from the rest of the staff.

However, independent Catrine is determined to do things her way, and break the rules. But underneath it all, she is lost, still mourning the loss of her mother and struggling to get along with her new family.

Helen's own heart is aching since the breakdown of her marriage with David, which isn’t helped when he returns to work at the hospital. Can she work side by side with the man she still loves?

Helen’s isn’t the only marriage that hangs in the balance, as Nurse Dora faces a shock that could mean the end of her own marriage…

Can love conquer all at the Nightingale Hospital?