Features

DNA by James Watson: additional notes part 3

DNA
Mary-Claire King
DNA
Mitochondrial Eve as cover girl
DNA
San hunters

!Gubi, a Namibian hunter-gatherer, one of the first African individuals, along with social activist Desmond Tutu (below), to have their genome sequenced. !Gubi hails from the Khoisan community, one of the most ancient and diverse human populations. His was the first genome from a minority population in Africa to be sequenced.

DNA
DNA
DNA
Abraham contemplates his complicated domestic arrangements.
DNA
Evolutionary response of body shape to climate: a heat-adapted Masai in Kenya and cold-adapted Inuit in Greenland
DNA
DNA
DNA
Alec Jeffreys, father of DNA fingerprinting
DNA
The first application of DNA fingerprinting: the X-ray film used by Alec Jeffreys to determine Andrew Sarbah’s true parentage
DNA
Colin Pitchfork, the English baker convicted of murdering two teenage girls in Leicestershire, in England in 1988. Pitchfork’s case was the first use of DNA fingerprinting to identify a murder suspect.
DNA
The Romanovs and their genetically certified remains
DNA
DNA
DNA
Pretender Anna Anderson in 1955, and Ingrid Bergman in the title role of Anastasia (1956), the movie inspired by Anderson’s claims
DNA
DNA
The remains of a discontent King Richard III were exhumed from a Leicester car park. DNA analysis sealed the identification of the last king of the Plantagenet dynasty.
DNA
DNA
A father’s lonely and ultimately forlorn crusade: The long-running campaign to clear James Hanratty’s name ran aground on DNA evidence.
DNA
DNA
Bruce Bryer, whose partial X chromosome deletion led to the identification of the DMD gene. He managed to lead a remarkably normal life and was an accomplished organist by the time he died after a car accident at the age of seventeen.
DNA
Lap-Chee Tsui, gene tracker
DNA
Arguably the remotest inhabited spot on the planet: Tristan da Cunha viewed from an uninhabited island nearby
DNA
In 2015, President Obama officially announced the Precision Medicine Initiative at the White House.
DNA
The karyotype—the full set of chromosomes—from a male with Down syndrome. Note the extra copy of chromosome 21.
DNA
Simone is a student with Down syndrome in Italy. He was photographed by Positive Exposure, a nonprofit organization that seeks to empower people living with difference.
DNA
Eight-cell embryo
DNA
Anne Morriss, CEO of GenePeeks, is banking on the potential of virtual progeny.
DNA
Cindy Cutshall, pioneering gene-therapy patient. After a visit to Cold Spring Harbor, she sent me her portrait of me in action.
DNA
DNA
When all the news was good: Alain Fischer and Marina Cavazzana-Calvo announce their breakthrough gene therapy triumph in April 2000.
DNA
CRISPR royalty: The scientific community broadly recognizes the major contributions of Emmanuelle Charpentier and Jennifer Doudna (left, winning the 2017 Japan Prize), and Feng Zhang (right), even as their host institutions battle for patent supremacy.
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
Caroline Bernardi, cancer survivor
DNA
John Diamond, author and journalist
DNA
Helen Hunt portrayed BRCA1 mapper Mary-Claire King in the 2013 film Decoding Annie Parker.
DNA
The long path from normal tissue to cancer’s spread: Classic studies by Bert Vogelstein, Ken Kinzler, and colleagues showed that colon and other cancers result from a sequential series of mutations in multiple genes.
DNA
Bob Weinberg (left) and Douglas Hanahan (right), researchers who have highlighted the essential hallmarks of cancer
DNA
DNA
The hallmarks of cancer, as laid out by Douglas Hanahan and Bob Weinberg. The latest iteration includes “avoiding immune destruction” and “deregulating cellular energetics” as core hallmarks.
DNA
Judah Folkman championed the inhibition of angiogenesis as a route to tackling cancer.
DNA
Drug discoverer Jay Bradner (left) reviews some Novartis research data.
DNA
A genome analysis report on a lung adenocarcinoma patient details genes harboring potentially actionable mutations.
DNA
Hitting the target: In one promising immunotherapy strategy, blocking the PD-1 receptor on the T-cell surface with a drug (green) boosts the tumor-killing properties of those white blood cells.